Palladium complexes and methods for using same in the treatment

Details Palladium complexes and methods for using same in the treatment Palladium complexes and methods for using same in the treatment

1993-11-26

1995-10-31

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554101, 568 64, 562606, 556136, C07B 4500

Patent

active

054630932

ABSTRACT:
Novel palladium complexes and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium).sub.m (lipoic acid).sub.n, wherein m and n are each independently 1 or 2. A process for preparing such complexes is also disclosed. In addition, a method of treatment of tumors and a method of treatment of psoriasis comprising administering the pharmaceutical compositions of the present invention are provided.

REFERENCES:
P. Reichard, From RNA to DNA, Why so Many Ribonuclease Reductases? Science 260:1773-1777 (1993).
J. A. hamilton et al., Cobamides and Ribonucleotide Reduction. VII. Cobalt (II)alamin as a Sensitive Probe for the Active Center of Ribonucleotide Reductase, Biochemistry 10(20):347-355 (1971).
A. I. McMullen, The Electrostatic Free Energy of Macromolecular Systems, Electronic Aspects of Biochemistry, Annals of the New York Academy of Sciences 158: 223-239 (1969).
M. D. Purugganan, Accelerated Electron Transfer Between Metal Complexes Mediated by DNA, Science 241:164514 1649 (1988).
C. Abate et al., Redox Regulation of Fos and Jun DNA--Binding Activity in Vitro, Science 249: 1157-1161 (1991).
S. Y. Shaw et al., Knotting of a DNA Chain During Ring Closure, Science 260: 533-536 (1993).
P. N. Campbell et al., Biochemistry Illustrated 2nd ed., Churchill Livingstone, Edinburgh, London, Melbourne and New York 1988, p. 126.
N. Hadjiliadis, Interaction of Thiamine and its Phosphate Esters with Pt (II) and Pd(II), Inorganic Chimica Acta 25:21-31 (1977).
L. Manuelidis, A View of Interphase Chromosomes, Science 250: 1533-1540 (1990).
J. J. Yunis et al., Heterochromatin, Satellite DNA, and Cell Function, Science 174 : 1200-1208 (1971).
G. J. Shugar et al., The Chemist's Ready Reference Handbook, McGraw-Hill, N.Y. p. 6.19 (1990).
M. St.C. Flett, Physical Aids to the Organic Chemist, Elsevier, Amsterdam--New York pp. 162-163 (1962).
L. Schotte, Spectrochemical Studies on Disulphides I. An Investigation of Some Linear and Cyclic Carboxylic Substituted Disulphides With Special Reference to the 1,2-Diothiolane System, Ark. Kemi 8 (56): 579-596 (1955).
L. Schotte, Studies on Sulphur Compounds Related to Glutaric and Pimelic Acid With Special Reference to the 1,2-Dithiolane System, Ark. Kemi, 9 (37): 441-469 (1956).
L. Schotte, Spectrochemical Studies on Disulphides IV. The Structure of Same Polysulphides, Ark. Kemi 9 (29): 361-376 (1956).
J. I. Maloy, Factors Affecting the Shape of Current-Potential Curves, Journal of Chem. Ed. 60(4): 285-289 (1983).
R. G. Finke et al., Radical Cage Effects in Coenzyme B.sub.12 : Radical Trapping, Product and Kinetic Studies, J. Inorg. Biochem. 51(1 and 2): 221 (1993).
R. Witkus, Stiensma et al., Berbee et al., Yeast Biology, Science 257: 1610 (1992).

Affiliated with

Also associated with

Rating

Palladium complexes and methods for using same in the treatment does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Palladium complexes and methods for using same in the treatment , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Palladium complexes and methods for using same in the treatment will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1773554