Palladium catalyzed nucleoside modifications methods using nucle

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 276, 536 2761, 536 2762, 536 278, 536 2781, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 1900

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057192731

ABSTRACT:
This invention discloses a method for the preparation modified nucleosides using a palladium catalyst, a nucleophile and carbon monoxide.

REFERENCES:
patent: 5047519 (1991-09-01), Hobbs, Jr. et al.
patent: 5053499 (1991-10-01), Kojima et al.
patent: 5420276 (1995-05-01), Norbeck
patent: 5428149 (1995-06-01), Eaton
Van Aerschot et al. Antiviral Activity of C-Alkylated Purine Nucleosides Obtained by Cross-Coupling with Tetraalkyltin Reagents, Journal of Medicinal Chemistry, 36:2938-2942 (1993).
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Tronchet et al. (1988) Nucleosides & Nucleotides, 7:249.
Tuerk and Gold (1990) Science 249:505.
U.S. Patent App. Ser. No. 08/347,60, Tu and Eaton, filed Dec. 1, 1994, entitled "Purine Nucleoside Modifications by Palladium Catalyzed Methods".
Hacksell and Daes, Jr. (1983) J. Org. Chem. 48:2870.
Hobbs et al. (1973) Biochemistry 12:5138.
Ikehara and Tada (1968) in Synthetic Procedures in Nucleic Acid Chemistry, Zorbach, W.W.; Tipson, R.S. Eds.; John Wiley and Sons, NY; p. 189.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Joyce (1989) Gene 82:83.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn et al. (1969) PNAS 63:805.
Levisohn et al. (1969) PNAS 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Pieken et al. (1991) Science 253:314.
Robertson and Joyce (1990) Nature 344:467.
Ruth and Bergstrom (1978) J. Org. Chem. 43:2870.
Sagi et al. (1994) J. Med. Chem. 37:1307.
Sessler et al. (1993) J. Am. Chem. Soc. 115:10418.
Shibahara et al. (1987) Nucliec Acids Res. 15:4403.
Sproat et al. (1989) Nucleic Acids Res. 17:3373.
Arai and Daves, Jr. (1978) J. Am. Chem. Soc. 100:287.
Bergstrom et al. (1981) J. Org. Chem. 46:1432.
Bergstrom and Ruth (1976) J. Am. Chem. Soc. 98:1587.
Bergstrom et al. (1982) J. Org. Chem. 47:2174.
Crisp (1989) Syn. Commun. 19:2117.
Dreyer and Dervan (1985) Proc. Natl. Acad. Sci. USA 82:968.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Guschlbauer et al. (1977) Nucleic Acids Res. 4:1933.
Zhang et al., Organometallics, vol. 12, No. 5, pp. 1499-1500, (1993).
Fukuda et al., Z. fur Naturforschung, vol. 41(b), pp. 1571-1579, (1986).
Ono et al., Bioorganic & Medicinal Letters, vol. 4, NO. 2, pp. 361-366, (1994).
Agathocleous et al., J. Chem. Soc. Perkins Trans. pp. 2317-2321, (1991).

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