Palladium catalyzed alkylative cyclization useful in synthesis o

Details Palladium catalyzed alkylative cyclization useful in synthesis o Palladium catalyzed alkylative cyclization useful in synthesis o

1993-04-20

1994-03-08

Pal, Asok

Chemistry of hydrocarbon compounds

Alicyclic compound synthesis

From nonhydrocarbon

585360, 585366, 570187, 570214, C07C 1336, C07C 1338, C07C40300

Patent

active

052929779

ABSTRACT:
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R.sub.1 where a substantially geometrically pure first precursor having the structure ##STR1## and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R.sub.2 hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R.sub.3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

REFERENCES:
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