Palladium catalyzed akylative cyclization useful in syntheses of

Details Palladium catalyzed akylative cyclization useful in syntheses of Palladium catalyzed akylative cyclization useful in syntheses of

1993-12-23

1995-08-29

Pal, Asok

Chemistry of hydrocarbon compounds

Alicyclic compound synthesis

From nonhydrocarbon

585360, 585366, 570187, 570214, C07C 1336, C07C 1338, C07C40300

Patent

active

054462258

ABSTRACT:
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R.sub.1 where a first precursor having the structure ##STR1## with X being a halide or a pseudo halide, and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R.sub.2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R.sub.3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

REFERENCES:
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