Paliperidone ketone

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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C544S287000

Reexamination Certificate

active

07932385

ABSTRACT:
A compound of formula (7.2) or an acid addition salt thereof.The compound can be used as a reference standard for monitoring the presence thereof in a paliperidone sample, including monitoring the completion of a paliperidone reaction. Reduction in the amount of the compound in paliperidone can be achieved by crystallization in the presence of a hydride reductant.

REFERENCES:
patent: 5158952 (1992-10-01), Janssen et al.
patent: 5688799 (1997-11-01), Vandenberk et al.
patent: 2009/0036470 (2009-02-01), Bartl et al.
patent: 2009/0156810 (2009-06-01), Bartl et al.
patent: 0 196 132 (1992-08-01), None
patent: 0 368 388 (1995-05-01), None
patent: WO 95/14691 (1995-06-01), None
patent: WO 2007/026377 (2007-03-01), None
patent: WO 2008/021342 (2008-02-01), None
A. Horvath et al., “Nitrogen Bridgehead Compounds. Part 30. Vilsmeier-Haack Formylation of 6, 7, 8, 9 Tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-ones” (J. Chem. Soc. Perkin Trans. 1, (1983) pp. 369-377.

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