Palatable trimethoprim oral solution

Details Palatable trimethoprim oral solution Palatable trimethoprim oral solution

1991-10-08

1997-12-16

Mullis, Jeffrey C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31505

Patent

active

056985622

ABSTRACT:
This invention is directed to an aqueous pharmaceutical composition with 1.25 mg to about 10 mg trimethoprim per mL (wt/vol) of solution and a compound of suitable acid strength to permit the dissolving of trimethoprim at the appropriate concentration, with the composition having a pH of less than 6.0. This composition is particularly useful for pediatric oral use.

REFERENCES:
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patent: 3985876 (1976-10-01), Hazlett et al.
patent: 4198429 (1980-04-01), Bartmann et al.
patent: 4645662 (1987-02-01), Nakashima et al.
patent: 4935225 (1990-06-01), Curtis et al.
patent: 4971785 (1990-11-01), Wilson et al.
patent: 5338732 (1994-08-01), Atzinger et al.
"Trimethoprim in Pediatric Urinary Tract Infection" Child Nephrol. Urol. 1988-1989; 9: 77-81 Rajkumar et al.
Manius in: Flory, ed. Analytical Profiles of Drug Substances, vol. 7 (Academic Press, 1978), pp. 445-475.

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