Painless injectable compositions containing salts of...

Details Painless injectable compositions containing salts of... Painless injectable compositions containing salts of...

2003-10-22

2008-10-28

Puttlitz, Karl J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C562S491000

Reexamination Certificate

active

07442832

ABSTRACT:
The invention relates to pharmaceutical compositions of alkylammonium salts of 2-aryipropionic acids, including ketoprofen, ibuprofen, naproxen and tiaprofenic acid. The compositions are suitable for parenteral administration arid, due to buffering at pH 8 to 9, cause less pain upon injection than previously known composition.

REFERENCES:
patent: 5895789 (1999-04-01), Gentile et al.
patent: 6342530 (2002-01-01), Darko
patent: WO-97/24114 (1997-07-01), None
Anacardio et al., Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene®) and pharmaceutical products frequently used for combined therapy by intravenous administration, Journal of Pharmaceutical and Biomedical Analysis vol. 32, Issue 6 , Aug. 21, 2003, pp. 1235-1241.
G.A. Brazeau et al., Journal of Pharmaceutical Sciences, vol. 87, No. 6, Jun. 1998, pp. 667-677.
J. Scott et al., Pain, vol. 2, 1976, pp. 175-184.

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