Pain-sensitive therapeutic wound dressings

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S015800, C514S016700, C514S017400, C424S445000, C602S042000, C602S048000, C604S304000

Reexamination Certificate

active

10554375

ABSTRACT:
The invention provides a wound dressing comprising a therapeutic agent and a matrix comprising polymers joined by cross-linkages which cross-linkages comprise oligopeptidic sequences which are cleavable by a kallikrein associated with wound fluid such that the rate of release of the therapeutic agent increases in the presence of elevated kallikrein levels.

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Del Nery, E. et al., “Comparison of human and porcine tissue kallikrein substrate specificities”, Immunopharmacology, 45 (1-3), 151-157 (1999).
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International Search Report dated Aug. 18, 2004.

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