PAI-2 conjugates for the treatment and imaging of cancer

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Reexamination Certificate

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C424S193100, C424S196110, C424S197110, C424S542000, C435S026000, C435S326000, C435S346000, C436S057000, C436S064000, C436S086000, C436S164000, C436S166000, C436S172000, C514S001000, C514S002600, C514S004300

Reexamination Certificate

active

07547441

ABSTRACT:
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises PAI-2 or a functional derivative, homologue, analogue, chemical equivalent or mimetic thereof, which PAI-2 is bound, linked, or otherwise associated with a toxin or label.

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