Pai-1 mutants

Details Pai-1 mutants Pai-1 mutants

1997-11-25

1999-02-02

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Vector, per se

530350, 530380, 536 231, 935 22, C12N 1500, C07H 2102, C07K 100, A61K 3514

Patent

active

058664130

ABSTRACT:
The present invention relates to serine protease mutants of the chymotrypsin superfamily that are resistant to inhibition by their cognate inhibitors, and genes that encode the same. The present invention also relates to serine protease inhibitor mutants that inhibit the serine protease mutants of the present invention, and genes that encode the same. The serine protease, mutants and serine protease inhibitor mutants are useful as, e.g., pharmacological agents.

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