PAF synthesis modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

548532, 548518, A61K 3140, C07D20722

Patent

active

055501486

ABSTRACT:
Compounds that selectively modulate the remodeling pathway of platelet activating factor (PAF) are described. Related pharmaceutical compositions and methods are also disclosed. These compounds, pharmaceutical compositions and methods are useful for reducing or eliminating inflammation.

REFERENCES:
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Hayakawa et al., Tetrahedron Letters 32(2):213-216, 1991.
Henderson, J. Allergy Clin. Immunol. 79(4):543-553, 1987.
Venable et al., J. Lipid Res. 34:691-702, 1993.
Braquet et al., Pharmacological Reviews 39(2):97-145, 1987.

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