Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-02-22
2005-02-22
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S510000
Reexamination Certificate
active
06858644
ABSTRACT:
Biologically active crystalline solvates of paclitaxel are precipitated using polar, aprotic, organic solvents. A pharmaceutical composition is also disclosed, as well as the preparation of the novel solvates and their uses as anti-tumor agents.
REFERENCES:
patent: 4492757 (1985-01-01), Kato et al.
patent: 4526718 (1985-07-01), Ross et al.
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4943528 (1990-07-01), Nakamura et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5053507 (1991-10-01), Moriuchi et al.
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5248796 (1993-09-01), Chen et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254580 (1993-10-01), Chen et al.
patent: 5272171 (1993-12-01), Ueda et al.
patent: 5274124 (1993-12-01), Holton
patent: 5279949 (1994-01-01), Nair
patent: 5284864 (1994-02-01), Holton et al.
patent: 5294637 (1994-03-01), Chen et al.
patent: 5300638 (1994-04-01), Farina et al.
patent: 5380916 (1995-01-01), Rao
patent: 5384399 (1995-01-01), Holton
patent: 5430160 (1995-07-01), Holton
patent: 5451392 (1995-09-01), Strobel et al.
patent: 5466834 (1995-11-01), Holton
patent: 5475120 (1995-12-01), Rao
patent: 5478736 (1995-12-01), Nair
patent: 5516676 (1996-05-01), Hanson et al.
patent: 5523219 (1996-06-01), Hanson et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
patent: 5574156 (1996-11-01), Holton
patent: 5646176 (1997-07-01), Golik et al.
patent: 5670673 (1997-09-01), Rao
patent: 5717115 (1998-02-01), Holton
patent: 5723634 (1998-03-01), Holton
patent: 5744333 (1998-04-01), Cociancich et al.
patent: 5760219 (1998-06-01), Holton et al.
patent: 5877205 (1999-03-01), Andersson
patent: 6017948 (2000-01-01), Rubinfeld et al.
patent: 6069260 (2000-05-01), Holton
patent: 6124481 (2000-09-01), Holton
patent: 6136989 (2000-10-01), Foo et al.
patent: 1 349 357 (1974-04-01), None
patent: 0 023 097 (1984-08-01), None
patent: 0 146 900 (1985-07-01), None
patent: 0 253 738 (1988-01-01), None
patent: 0 253 739 (1988-01-01), None
patent: 0 336 840 (1989-10-01), None
patent: 0 336 841 (1989-10-01), None
patent: 0 247378 (1990-09-01), None
patent: 0 404 586 (1990-12-01), None
patent: 0 405 104 (1991-01-01), None
patent: 0 421 283 (1991-04-01), None
patent: 0 495 718 (1992-07-01), None
patent: 0 414 610 (1993-05-01), None
patent: 0 569 281 (1993-11-01), None
patent: 0 582 469 (1994-02-01), None
patent: 0 534 708 (1995-09-01), None
patent: 0 553 780 (1995-09-01), None
patent: 0 428 376 (1996-01-01), None
patent: 0 529 483 (1996-02-01), None
patent: 0 537 905 (1996-03-01), None
patent: 0 534 707 (1996-12-01), None
patent: 0 558 959 (1997-04-01), None
patent: 0 400 971 (1998-07-01), None
patent: 0 604 910 (2000-06-01), None
patent: 0 552 041 (2000-08-01), None
patent: 0 717 041 (2002-08-01), None
patent: 0 534 709 (2003-01-01), None
patent: 200155 (1985-08-01), None
patent: WO 9010443 (1990-09-01), None
patent: WO 9207842 (1992-05-01), None
patent: WO 9209589 (1992-06-01), None
patent: WO 9302065 (1993-02-01), None
patent: WO 9306079 (1993-04-01), None
patent: WO 9306094 (1993-04-01), None
patent: WO 9709443 (1997-03-01), None
patent: 919224 (1991-11-01), None
Abdel-Magid, A. et al., “Metal-Assisted Aldol Condensation of Chiral α-Halogenated Imide Enolates: A Stereocontrolled Chiral Epoxide Synthesis”, J. Am. Chem. Soc., vol. 108, pp. 4595-4602 (1986).
Arbuck, S.G. et al., et al., Chapter 14: “Taxol: Clinical Results and Current Issues in Development”, Taxol: Science and Applications, CRC Press, Inc., publ., Suffness, M., ed., pp. 379-415 (1995).
Bartholomew, D. et al., “A Novel Rearrangement Reaction Conversion of 3-(chloromethyl)azetidin-2-ones to azetidine-3-caboxylic acid esters”, Tetrahedron Letters, vol. 32, No. 36, pp. 4795-4798.
Barton, D.H.R. et al., “Asymmetric Synthesis of 1,3,4-Trisubstituted and 3,4-Disubstituted 2-Azetidinones: Strategy Based on Use of D-Glucosamine as a Chiral Auxiliary in the Staudinger Reaction”, J. Chem. Soc. Perkin Trans. 1, pp. 3211-3212 (1990).
Borer, B.C. et al., “An Asymmetric Synthesis of a 3-hydroxy-β-lactam by Ketene-Imine Cycloaddition: Utilization of Chiral Ketenes from Carbohydrates”, Tetrahedron Letters, vol. 32, No. 8, pp. 1039-1040 (1991).
Borman, S., “New family of Taxol, Taxotere analogs developed”, Chem. & Engineering News, pp. 36-37 (Apr. 12, 1993).
Bose, A.K. et al., “Studies on β-Lactams. XXXVI. Monocyclic Cis β-Lactams via Penams and Cephams”, J. Org. Chem., vol. 39, No. 19, pp. 2877-2884 (1974).
Bose, A.K. et al., “Studies on Lactams. Part XVI. Stereochemistry of β-Lactam Formation”, Tetrahedron Letters, No. 34, pp. 3167-3170 (1971).
Bose, A.K. et al., “Studies on Lactams —V: 3-azido-2-azetidinones”, Tetrahedron, vol. 23, pp. 4769-4776 (1967).
Bose, A.K. et al., “Studies on the Mechanism of β-Lactam Formation”, Tetrahedron Letters, No. 40, pp. 4091-4094 (1972).
Brieva, R. et al., “Chemoenzynmatic Synthesis of the C-13 Side Chain of Taxol: Optically-Active 3-Hydroxy-4-phenyl β-Lactam Derivatives”, J. Org. Chem., vol. 58, pp. 1068-1075 (1993).
Burnett, D.A. et al., “Synthesis of 3-(1-Hydroxyethyl-2-azetidinones via Ester-Imine Condensations”, J. Org. Chem., vol. 50, pp. 5120-5123 (1985).
Chan, W.R. et al., “Taxa-4(16), 11-diene-5α,9α, 10β, 13β-tetraol, a New Taxane Derivative from the Heartwood of Yew (T. baccata L.): X-Ray Analysis of a p-Bromobenzoate Derivative”, Chemical Communications, No. 24, pp. 923-925 (1996).
Chen, S.-H. et al., “Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 2-deoxytaxol”, Tetrahedron Letters, vol. 34, No. 20, pp. 3205-3206 (1993).
Cooper, R.D.G. et al., “Chiral control of the Staudinger reaction”, Pure & Appl. Chem., vol. 59, No. 3, pp. 485-492 (1987).
Cosslo, F.P. et al., “Triphenylphosphine Dibromide and Dimethylsulfide Dibromide as Versatile Reagents for Beta-Lactam Synthesis”, Tetrahedron Letters, vol. 26, No. 25, pp. 3041-3044 (1985).
Della Casa, D.P. et al., “The Isolation of Seven New Taxane Derivatives from the Heartwood of Yew (Taxus baccataL.)”, Chemical Communications, pp. 1282-1283 (1969).
Denis, J.-N. et al., “A Highly Efficient, Practical Approach to Natural Taxol”, vol. 110, pp. 5917-5919 (1988).
Denis, J.-N. et al., “An Efficient, Enantioselective Synthesis of the Taxol Side Chain”, vol. 51, pp. 46-50 (1986).
Denis, J.-N. et al., “An Improved Synthesis of the Taxol Side Chain and of RP 56976”, J. Org. Chem., vol. 55, pp. 1957-1959 (1990).
Deutsch, H.M. et al., “Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol with Potent Antitumor Activity”, vol. 32, pp. 788-792 (1989).
Dordick, J.S., “Designing Enzymes for Use in Organic Solvents”, Biotechnol. Prog., vol. 8, pp. 259-267 (1992).
Ettotouati, L. et al., “Plantes de Nouvelle-Calédonie. 114. Taxanes isolés des feuilles d'Austrotaxus spicataCompton (Taxacées)”, Bulletin de la Société Chimique de France, No. 4, pp. 749-755 (1988).
Evans, D.A. et al., “The Asymmetric Synthesis of β-Lactam Antibiotics—1. Application of Chiral Oxazolidones in the Staudinger Reaction”, Tetrahedron Letters, vol. 26, No. 32, pp. 3783-3786 (1985).
Farina, V. et al., “The Chemistry of Taxanes: Unexpect
Benigni Daniel A.
DiMarco John D.
Gougoutas Jack Z.
Baxam Deanna L.
Bristol-Myers Squibb Co.
Owens Amelia A.
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