Paclitaxel enhancer compounds

Details Paclitaxel enhancer compounds Paclitaxel enhancer compounds

2008-05-06

2008-05-06

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S559000, C514S614000, C514S615000, C549S510000, C549S511000, C564S074000, C564S148000, C564S149000, C564S151000

Reexamination Certificate

active

11244427

ABSTRACT:
One embodiment of the present invention is a compound represented by the Structural Formula (I):Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—.R1is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R2-R4are independently —H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R1and R3taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2and R4taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring.R5-R6are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group.R7and R8are each independently —H, an aliphatic or substituted aliphatic group, or R7is —H and R8is a substituted or unsubstituted aryl group, or, R7and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group.Z is ═O or ═S.Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.

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