Liquid purification or separation – With means to add treating material – Chromatography
Patent
1993-03-10
1995-08-15
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
2105021, 210656, 423308, 423311, 502400, B01D 1508
Patent
active
054416353
ABSTRACT:
Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof.
A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m.
A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense structure with a porosity of no more than 5%.
A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):
REFERENCES:
patent: 3943072 (1976-03-01), Thomson et al.
patent: 3989649 (1976-11-01), Kaiho
patent: 4045353 (1977-08-01), Kosaka
patent: 4219590 (1980-08-01), Shibazaki et al.
patent: 4293426 (1981-10-01), Gago
patent: 4470839 (1984-09-01), Gago
patent: 4477492 (1984-10-01), Bergna
patent: 4497078 (1985-02-01), Niwa
patent: 4503157 (1985-03-01), Hatahira
patent: 4544601 (1985-10-01), Yamaguchi et al.
patent: 4693986 (1987-09-01), Vit et al.
patent: 4711769 (1987-12-01), Inoue et al.
patent: 4743377 (1988-05-01), Ohtsu et al.
Opposition to European Patent No. 0 252 472 filed by Merck on Jun. 28, 1991, and English translation.
Bio Industry, vol. 2, No. 9, pp. 760-763, issued Sep. 1, 1985, and English translation of Table I and Photo 2.
Tsutomu Kawasaki et al, "High-Performance liquid chromatography using spherical aggregates of hydroxyapatite micro-crystals as adsorbent", European J. of Biochem, vol. 157, No. 2, pp. 291-295.
Rompps Chemie-Lexikon, Dr. Otto-Albrecht Neumuller, p. 3328, section entitled "Poren" and English translation (1987).
Rootare & Spencer, "A Computer Program for Pore Volume and Pore Area Distribution . . . ", Powder Technology, vol. 6, pp. 17-23, (1972).
Derwent Abstract of GB 1421531 Dec. 15, 1971.
Substantiation filed by Merck on May 13, 1992, and English translation.
A. Berthod, "Silica: backbone material of liquid chromatographic column packings", CHROM, 23, Abstract, pp. 16 and 17, Nov. 18, 1991.
Abstract and claims 1 and 2 of PCT/US90/00930 (WO 91/00762) Jan. 24, 1991.
Kadoya "A New Spherical Hydroxyapatite" Journal of Liquid Chromatography, vol. 9(16) pp. 3543-3557 (1986).
Chander, An XPS Study of the Fluoride Uptake by Hydroxyapatite, Colloid & Surfaces, vol. 13, 137-144 (1985).
Napper, The Dissolution Kinetics of Hydroxyapatite in the Presence of Link Poisons, J. Dent. Res., vol. 45, pp. 1775-1783 (1966).
Moreno, Physicochemical Aspects of Fluoride-Apatite Systems Relevant to the Study of Dental Caries, in in Caries Res., vol. 11, (Suppl. 1) pp. 142-171 (1977).
Amiad, Fluoride Influence on Mineralization, Caries Res., vol. 13, pp. 250-258 (1979).
Chemical Abstracts, vol. 107, No. 101608n, entitled "Calcium Phosphate Sintered Body with Apatite Coating" (Sep. 1987).
Chemical Abstracts, vol. 77, No. 126605t entitled "Affinity of Citric Acid for Mineral Phase in Calcified Tissues" (1972).
Ichitsuka Takeshi
Ogawa Tetsuro
Sumita Masaya
Asahi Kogaku Kogyo Kabushiki Kaisha
Therkorn Ernest G.
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