Chemistry: molecular biology and microbiology – Apparatus – Microorganism preservation – storage – or transport apparatus
Patent
1999-05-26
2000-11-14
Redding, David A.
Chemistry: molecular biology and microbiology
Apparatus
Microorganism preservation, storage, or transport apparatus
4352884, 4352975, 4353053, C12M 300
Patent
active
061468835
ABSTRACT:
A disposable or recyclable device is provided for packaging and transporting ready-to-use viable cell monolayers, particularly confluent cell monolayers. The device includes a liquid impervious housing having a housing base defining an interior filled with fluid medium, a plurality of detachable and spatially separated permeable membrane inserts each having a confluent cell monolayer attached thereon, and a removable lid. The permeable membrane inserts are disposed in an interior of the housing in a spatially addressable array and the housing base is sealed by the lid so as to separate the membrane inserts from an external environment and to exclude excess air from the fluid filled interior. The device optionally includes a disposable or recyclable environmental control system for regulating chemical and/or physical conditions during transport. Cell monolayers of the device are protected from mechanical injury so that assays or other experiments requiring even growth and dense cell populations can be performed upon delivery. The device of the invention also can be utilized for packaging and transporting multiple different types of cell monolayers on a variety of solid and microporous substrata, the cells normalized to any desired stage of cell cycle and/or growth, without the need to recalibrate cell cycle or synchronize growth upon receipt.
REFERENCES:
patent: 3186917 (1965-06-01), Gerhardt et al.
patent: 3386912 (1968-06-01), Lazare
patent: 3508656 (1970-04-01), Serfass et al.
patent: 3520803 (1970-07-01), Iaconelli
patent: 3590634 (1971-07-01), Pasternak et al.
patent: 3684097 (1972-08-01), Mathewson, Jr. et al.
patent: 3904480 (1975-09-01), Hull et al.
patent: 3963613 (1976-06-01), Chibata et al.
patent: 4087327 (1978-05-01), Feder et al.
patent: 4143765 (1979-03-01), Moss, III
patent: 4212742 (1980-07-01), Solomon et al.
patent: 4293399 (1981-10-01), Belanger et al.
patent: 4395492 (1983-07-01), Rees
patent: 4446229 (1984-05-01), Indech
patent: 4508819 (1985-04-01), Rose
patent: 4537860 (1985-08-01), Tolbert et al.
patent: 4661458 (1987-04-01), Berry et al.
patent: 4666853 (1987-05-01), Meserol et al.
patent: 4667504 (1987-05-01), Hobson
patent: 4686190 (1987-08-01), Cramer et al.
patent: 4734372 (1988-03-01), Rotman
patent: 4734373 (1988-03-01), Bartal
patent: 4852389 (1989-08-01), Mayer et al.
patent: 4938931 (1990-07-01), Cussler
patent: 5026649 (1991-06-01), Lyman et al.
patent: 5084393 (1992-01-01), Rogalsky
patent: 5139951 (1992-08-01), Butz et al.
patent: 5141873 (1992-08-01), Steudle et al.
patent: 5160604 (1992-11-01), Nakamura et al.
patent: 5183760 (1993-02-01), Sweetana et al.
patent: 5190878 (1993-03-01), Wilhelm
patent: 5228569 (1993-07-01), House
patent: 5415277 (1995-05-01), Bernsten
patent: 5466602 (1995-11-01), Lyman et al.
patent: 5693537 (1997-12-01), Wilson et al.
patent: 5759851 (1998-06-01), Mathus
patent: 5882922 (1999-03-01), Tyndorf et al.
Cheryan et al., "Membrane Bioreactors", Membrane Separations in BiotechnologyMembrane Separations in Biotechnology, (1986) pp. 284-300, published by Marcel Dekker, Inc., New York, New York.
Grass et al., "In Vitro Measurement of Gastrointestinal Tissue Permeability Using a New Diffusion Cell", Pharmaceutical Research, (1988) vol. 5, No. 6, pp 372 376.
Minuth et al., "Approach to an Organo-Typical Environment for Cultured Cells and Tissues", BioTechniques (1996) vol. 20, No. 3, pp. 498-501.
Minuth et al., "Construction of an Apparatus for Perfusion Cell Cultures Which Enables In Vitro Experiments Under Organotypic Conditions", European Journal of Cell Biology (1992) vol. 57, No. 1, pp. 132-137.
Perantoni et al., "Properties of Wilms' Tumor Line (TuWi) and Pig Kidney Line (LLC-PK.sub.1) Typical of Normal Kidney Tubular Epithelium", In Vitro (1979) vol. 15, No. 6, pp. 446-454.
Schinkel et al., "Absence of the mdrla P-Glycoprotein in Mice Affects Tissue Distribution and Pharmacokinetics of Dexamethasone, Digoxin, and Cyclosporin A", J. Clin. Invest. (1995) vol. 96, pp. 1698-1705.
Schoenwald et al., "Corneal Penetration Behavior of a .beta.-Blocking Agents I: Physicochemical Factors", Journal of Pharmaceutical Sciences (1983) vol. 72, No. 11, pp. 1256-1281.
Ussing et al., "Active Transport of Sodium as the Source of Electric Current in the Short-Circuited Isolated Frog Skin", Acta Phys. Scandinav. (1950) vol. 23, pp. 110-127.
Navicyte, Inc.
Redding David A.
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