Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1989-03-23
1990-07-17
Richman, Barry S.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 81, 436161, 73 611C, G01N 3002
Patent
active
049420186
ABSTRACT:
Solvent composition gradients in high performance liquid chromatography (HPLC) are generated with a packed bed gradient generator. Natural dispersion occurs in flow through a bed of particles due to eddy and molecular diffusion. This dispersion changes a sharply defined front between two solvents into a desirable error function type gradient profile at the interface between the solvents. The packed-bed gradient generator is a cylindrical tube filled with chemically inert glass beads. Other axial column contours such as a double taper column or bell-shaped entrance and exit regions can be used to tailor the gradient profile. The static packed-bed gradient generator can be placed either on the low pressure inlet side of the high pressure pump, or the high pressure outlet side of the pump. While low pressure operation may provide added convenience, high pressure operation provides additional pulse dampening ability. The high pressure placement of the packed-bed generator would be the only option for use with syringe pumps common in microbore HPLC.
REFERENCES:
patent: 3934456 (1976-01-01), Munk
patent: 4130394 (1987-12-01), Negersmith
Henley et al; Equilibrium-Stage Separation Operations in Chemical Engineering; John Wiley & Sons, Inc; New York; 1981 pp. 72-73.
L. Synder and J. Kirkland; "Introduction to Modern Liquid Chromatography"; 1979, pp. 663-719, 840-843.
L. Snyder; "Comparisons of Normal Elution, Coupled-Columns, and Solvent, Flow or Temperature Programming in Liquid Chromatography"; Journal of Chromatographic Science; vol. 8; Dec., 1970, pp. 692-706.
P. Jandera and J. Churacek; "Gradient Elution in Column Liquid Chromatography"; 1985, pp. 185-242.
J. Giddens; "Dynamics of Chromatography"; 1965, pp. 86-89.
LDC Analytical Inc.
McMahon Timothy M.
Richman Barry S.
LandOfFree
Packed bed gradient generator for high performance liquid chroma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Packed bed gradient generator for high performance liquid chroma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Packed bed gradient generator for high performance liquid chroma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-94286