Packed bed bioreactor

Details Packed bed bioreactor Packed bed bioreactor

1987-05-26

1989-05-23

Garrett, Robert E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43524023, 435288, 435284, 210617, 210618, C12N 500, C12M 140, C12M 300

Patent

active

048330833

ABSTRACT:
A bioreactor for anchorage or nonanchorage dependent cells or for immobilized enzymes that is capable of achieving high cell densities or concentrations of reaction products is disclosed. The bioreactor is capable of being easily scaled up. The bioreactor utilizes horizontal or radial flow of the culture or growth medium across a packed bed of microcarriers with attached cells or enzymes. The radial flow utilized by the chamber minimizes the non-optimal culture perfusion problems and maximizes the uniformity of medium delivery and cell and/or enzyme viability. The cell culture chamber possess the capability for the production of many industrially important and useful products, particularly in the medical, pharmaceutical, food, agricultural, environmental and purification industries. In the medical and pharmaceutical industries, the large scale production of therapeutically important substances such as anti-tumor factors, hormones, viral antigens, enzymes, interferons and other valuable biomolecules, is greatly facilitated.

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