Packaging of positive-strand RNA virus replicon particles

Details Packaging of positive-strand RNA virus replicon particles Packaging of positive-strand RNA virus replicon particles

2006-04-25

2006-04-25

Guzo, David (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S456000, C435S235100

Reexamination Certificate

active

07034141

ABSTRACT:
The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.

REFERENCES:
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