Dispensing – With filter – Associated with vent passage
Patent
1991-04-29
1993-10-05
Shaver, Kevin P.
Dispensing
With filter
Associated with vent passage
210266, 210475, 210501, 222129, 222190, 222212, 222525, B67D 558
Patent
active
052497127
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to the industry concerned with the packaging and purification of liquids, more particularly in containers provided with an incorporated obturator, and especially the physical or chemical modification of a liquid.
The invention finds a particularly advantageous application in the pharmaceutical industry, especially in regard to therapeutic products for local application as employed in ophthalmology, dermatology, gynecology as well as in cosmetology. The invention is of course also applicable, for example, in the field of bottles of household products or chemical products.
There exists a known type of container, especially of plastic material with elastically deformable walls and a neck containing an inseparable obturator which is movable at will between a closed position and an open position of the container, of the type provided in plug valves or slide valves.
It is sometimes necessary to modify the liquid delivered, in particular by extraction of an undesirable substance by passing through a filter element or purifying element which is external to the container or else by extemporaneous addition of a substance which is soluble in the liquid contained in the container, which is fairly common in the case of therapeutic solutions of lyophilizates and is usually carried out by confinement of the additional substance in a breakable envelope within the container until the moment of use.
The answers given to these packaging problems up to the present time are subject to practical disadvantages which arise in particular from the complexity of the elements to be assembled and on the other hand from the fragility of elements which are external to the container or in contact with the liquid prior to use. Moreover, it is necessary to design a specific package for each application, which limits production series and influences industrial costs.
SUMMARY OF THE INVENTION
One object of the invention is to provide a readily standardizable package for liquids which makes it possible to keep the liquid isolated from the exterior and from any additional substances or from filtering or purifying elements up to the moment of use, composed of elements which are simple to produce and to assemble in order to constitute a unitary package which is easy to handle, rugged and inexpensive.
Another object of the invention is to carry out extemporaneous purification of small fractional quantities which are withdrawn from a liquid within a container as it is being used.
For the preservation of such products during storage, in particular for products which are intended for a therapeutic application, it is often necessary and even legally compulsory to add preservatives dissolved in the stored liquid. In the majority of instances, however, these preservatives have undesirable effects after or during therapeutic application. It is thus often found to produce irritations which inhibit the action of scar-forming products or the like.
One is thus faced with a problem which is apparently difficult to solve : the need to keep a therapeutic solution in the sterile state during a suitable period of storage which involves the addition of a preservative and the need to apply the same sterile solution in the pure state and therefore without preservative. This problem is further complicated by the fact that the use of a package is fragmented in the majority of local therapeutic applications. Once the container has been opened, the liquid is in contact with the surrounding air and loses its sterility if it does not contain any preservative.
A common solution to this problem which is adopted at the present time consists in packaging the sterile liquids in containers corresponding in each case to an entire treatment, which may be completely purified prior to application subject, however, to the risk of a loss of sterility. It has also been proposed to protect the sterility of the contents of a container between successive fractional withdrawals by placing a sterilizing filter at the outlet of the container.
A filter of th
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patent: 4938389 (1990-07-01), Rossi et al.
patent: 4947986 (1990-08-01), Ballu
patent: 5013459 (1991-05-01), Gettings et al.
patent: 5056689 (1991-10-01), Heyl et al.
Chibret Henri
Lontrade Jean-Pierre
Schwadrohn Gerard
Shaver Kevin P.
Transphyto S.A.
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