Packaging cells for recombinant adenovirus

Details Packaging cells for recombinant adenovirus Packaging cells for recombinant adenovirus

2006-03-20

2010-10-19

Schultz, J D (Department: 1633)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S235100, C435S006120, C435S325000, C514S04400A, C424S093100

Reexamination Certificate

active

07816104

ABSTRACT:
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.

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