Packaging cell lines for the continuous production of...

Details Packaging cell lines for the continuous production of... Packaging cell lines for the continuous production of...

2008-05-27

2008-05-27

Chen, Stacy B. (Department: 1648)

Chemistry: molecular biology and microbiology

Vector, per se

C424S218100

Reexamination Certificate

active

07378272

ABSTRACT:
The present invention pertains to packaging cell lines useful for the production of viral vectors, particularly packaging cell lines for continuous production of Sindbis viral vectors at high efficiency. The packaging cell line comprises an insect cell having DNA that encodes alphavirus structural proteins, replicase and a replicon.

REFERENCES:
patent: 5789245 (1998-08-01), Dubensky, Jr. et al.
patent: 6943015 (2005-09-01), Frolov et al.
Hertz et al. Host-dependent evolution of the sindbis virus promoter for subgenomic mRNA synthesis, Journal of Virology, 1995, 69(12):7775-7781.
Theilmann et al, Molecular analysis of the trans-activating IE-2 gene ofOrgyia pseudotsugatamulticapsid nuclear polyhedrosis virus, Virology, 1992, 187:84-96.
Polo et al, “Stable Alphavirus Packaging Cell Lines for Sindbis Virus and Semliki Forest Virus-Derived Vectors,”Proc. Natl. Acad. Sci. USA, Apr. 1999, vol. 96, pp. 4598-4603.

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