Special receptacle or package – Including ancillary article contacting medium – Gas medium
Patent
1985-10-02
1987-05-12
Price, William
Special receptacle or package
Including ancillary article contacting medium
Gas medium
514166, B65D 8124, A61K 3160
Patent
active
046642560
ABSTRACT:
A packaged enema solution or suspension consisting essentially of an effective amount of 5-ASA or a pharmaceutically acceptable salt or ester thereof, a chelating agent, an antioxidant and a buffer, the solution or suspension having a pH value of from 4 to 7 and being contained in a plastic bottle under an inert gas, the plastic bottle being packaged in a diffusion-tight light-impervious package in the same inert gas as is present in the bottle.
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Khan et al, "An Experiment to Determine the Active Therapeutic Moiety of Sulphasalazine", Lancet, Oct. 29, 1977, pp. 892-895.
Campieri et al, "Treatment of Ulcerative Colitis with High-Dose 5-Amino-Salicyclic Acid Enemas", Lancet, Aug. 8, 1981, pp. 270-271.
Allgayer et al, "Determination of the PK Values of 5-Aminosalicyclic Acid and N-acetylaminosalicyclic Acid and Comparison of the pH Dependent Lipid-Water Partition Coefficients of Sulphasalizine and its Metabolites", Arzneim, Forsch. 35(II), No. 9 (1985), p. 1457-5.
Rhodes, "Medical Treatment of Ulcerative Colitis and Crohn's Disease", Journal of Clinical and Hospital Pharmacy (1983), 8, 219-232.
Bondesen, S. et al, "5-Aminosalicylic Acid Enemas in Patients with Active Ulcertative Colitis", Scand. J. Gastroenterol 19: 677-687 (1984).
Binder, V., "Tropical 5-Aminosalicyclic Acid Versus Prednisolone in Ulcerative Proctosigmoiditis", Digestive Diseases and Sciences, U.S.A., Oct. 3, 1985.
Willoughby, C. et al, "5-Aminosalicyclic Acid (PENTASA) in Enema Form for the Treatment of Active Ulcerative Colitis", Submitted to Scand. J. Gastroenterol.
Farmaceutisk Laboratorium Ferring A/S
Foster Jimmy G.
Price William
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