Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-03-27
2000-02-01
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435375, 536 231, 536 2431, C17Q 168, C07H 2104
Patent
active
060201355
ABSTRACT:
Many genes are identified as being p53-regulated which were not heretofore known to be p53-regulated. This includes both genes whose expression is induced and genes whose expression is repressed by the expression of wild-type p53. Monitoring expression of these genes is used to provide indications of p53 status in a cell. Such monitoring can also be used to screen for useful anti-cancer therapeutics, as well as for substances which are carcinogenic. Defects in p53 can be bypassed by supplying p53 induced genes to cells. Defects in p53 can also be bypassed by supplying antisense constructs to p53-repressed genes.
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Gish Kurt Carlyle
Levine Arnold J.
Mack David H.
Murphy Maureen Elizabeth
Tom Edward Yat Wah
Affymetrix Inc.
LeGuyader John L.
Princeton University
Shibuya Mark L.
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