Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-03-14
2006-03-14
Cook, Rebecca (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S368000, C514S375000, C514S393000
Reexamination Certificate
active
07012087
ABSTRACT:
The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
REFERENCES:
patent: 4497817 (1985-02-01), Murase et al.
patent: 5919808 (1999-07-01), Petrie et al.
patent: 0 430 334 (1991-06-01), None
patent: 7291976 (1995-11-01), None
patent: 11029475 (1999-02-01), None
patent: 11106340 (1999-04-01), None
patent: WO96/28454 (1996-09-01), None
patent: WO98/17267 (1998-04-01), None
CA130:119241, chernov et al, Oncogen, 1997, 14(21), 2503-2510, abstract.
Mase et al., J. Med. Chem., 1986, 29, 386-394.
Komarova et al., “Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53,”Oncogene, 17, pp. 1089-1096 (1998).
Andreani et al., “Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase,”Journal of Medicinal Chemistry, vol. 38, pp. 1090-1097 (1995).
Balse et al., “Condensed tetrahydrobenzothiazoles: Part III—synthesis fo 2-aryl-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazoles & 1,2,3,4-tetrahydrobenzimid-azo[2,1-b]benzothiazoles & their 4/5 carbethoxy derivatives,”Indian Journal of Chemistry, vol. 19B, pp. 263-265 (1980).
Singh et al., “Heterocyclic systems containing bridgehead nitrogen atom: Part XXV—Syntheses of imidazo[2,1-b]benzothiazoles & quinoxalino[2,3:4′,5′]-imidazo[2′,1′-b] benzothiazoles,”Indian J. Chem., vol. 14B, pp. 997-998 (1976).
Naito et al., “Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells,”J. Heterocyclic Chem., 34, pp. 1763-1767 (1997).
Kochergin et al., “Action of α-halo ketones on 2-mercaptoimidazoles,”J. Gen. Chem U.S.S.R., 26, pp. 483-489 (1980).
P.G. Komarov et al., A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy,Science, 285, pp. 1733-1737 (1999).
K.K. Bhargava et al., Tetramisole analogues as inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines,Journal of Medicinal Chemistry, 20, No. 4, pp. 563-566 (1977).
C.L. Baird et al., Synthesis, characterization and antitumor activity of platinum triamine complexes containing imidazothiazole ligands,Inorganica Chimica Acta, 256, pp. 253-262 (1997).
A. Singh et al., Heterocyclic systems containing bridgehead nitrogen atom: Part XXV—syntheses of imidazo[2,1-β]benzothiazoles & quinoxalino[2,3:4′5′]imidazo[2′,1′-β]benzothiazoles,Indian J. Chem., 14B, pp. 997-998 (1976).
S. Tasaka et al., Synthesis of 2-phenylimidazo[2,1-β]benzothiazole derivatives as modulators of multidrug resistance for tumor cells,J. Heterocyclic Chemistry, 34, pp. 1763-1767 (1997).
S.N. Sawhney et al., Synthesis & anti-inflammatory activity of some 6-alkyl- or aryl-imidazo[2,1-β] thiazole-3-acetic acids,Indian J. Chem., 16B, pp. 523-524(1978).
E.A. Komarova et al., Could p53 be a target for therapeutic suppression?,Seminars in Cancer Biology, 8, No. 5, pp. 389-400 (1998).
R.J.C. Steele et al., The p53 tumour suppressor gene,British Journal of Surgery, 85, pp. 1460-1467 (1998).
E.A. Komarova et al., Transgenic mice with p53-responsive IacZ:p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo,The EMBO Journal, 16, No. 6, pp. 1391-1400 (1997).
Singh et al.,Indian J. Chem., Sect. B, 14B(2), 997-8 (1976).
Gudkov Andrei V.
Komarov Pavel G.
Komarova Elena A.
Cook Rebecca
Marshall & Gerstein & Borun LLP
The Board of Trustees of the University of Illinois
LandOfFree
p53 inhibitors and therapeutic use of the same does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with p53 inhibitors and therapeutic use of the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and p53 inhibitors and therapeutic use of the same will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3584089