Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-08-03
2009-08-25
McGarry, Sean R (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S006120, C435S375000, C435S377000, C536S023100, C536S024100, C536S024500
Reexamination Certificate
active
07579329
ABSTRACT:
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is also expressed in normal and tumour lung tissue and in breast cancer cells and may have a correlation with lung and breast cancer. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide, polypeptide, fragments thereof and inhibitors thereof, include the treatment of dermatological disorders, cancer and certain brain disorders.
REFERENCES:
patent: 5998148 (1999-12-01), Bennett et al.
patent: 6686338 (2004-02-01), Iversen
patent: WO 97/49815 (1997-12-01), None
Branch, A. TIBS, vol. 23:45-50, Feb. 1998.
Agrawal, S. TIBTECH vol. 14:376-387, Oct. 1996.
Nelson, D. Archives of Biochemistry and Biophysics vol. 371(2):345-347, Nov. 15, 1999.
White, Jay A. et al. “Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.” Proceedings of the National Academy of Sciences of the United States, 97(2): 6403-6408 (2000).
Miller, Wilson H. Jr. “The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer.” Cancer, 83(8), 1471-1482 (1998).
Database EMBL ′Online! EBI; Acc. No. AC007002. Mar. 12, 1999 Sulston J.E., Waterston R.: “Homo sapiensBAC clone RP11-493L16 from 2, complete cds” XP002168113 abstract.
Njar, V.C.O. et al. “Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.” Bioorganic & Medicinal Chemistry Letters, 10(17): 1905-1908 (2000).
Jones Glenville
Petkovich Martin P.
Ramshaw Heather
White Jay A.
Cytochroma Inc.
Marshall & Gerstein & Borun LLP
McGarry Sean R
LandOfFree
P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4075331