P38 MAP kinase inhibitors

Details P38 MAP kinase inhibitors P38 MAP kinase inhibitors

2007-05-01

2011-10-25

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C544S301000, C514S274000, C514S349000

Reexamination Certificate

active

08044211

ABSTRACT:
Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD:wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6is hydrogen or optionally substituted C1-C3alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2)z—X1-L1-Y—NH—CHR1R2wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1are as defined in the specification; R1is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2is the side chain of a natural or non-natural alpha amino acid.

REFERENCES:
patent: 03/076405 (2003-09-01), None

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