Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2011-03-15
2011-03-15
Chen, Shin-Lin (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S013000, C800S018000
Reexamination Certificate
active
07906701
ABSTRACT:
The present invention relates to a transgenic animal wherein DNA encoding p300 and a promoter exerting its activity in myocardial cells are introduced, and a screening method using the same.
REFERENCES:
Kappel et al., 1992, Current Opinion in Biotechnology, vol. 3, p. 548-553.
Wall, R. J., 1996, Theriogenology, vol. 45, p. 45-68.
Sigmund, C., Jun. 2000, Arterioscler. Thromb. Vasc. Biol., p. 1425-1429.
Houdebine, L-M., 2002, Journal of Biotechnology, vol. 98, p. 145-160.
Mercier et al., 1997, “The modification of milk protein composition through transgenesis: progress and problems,” In: Transgenic Animals: Generation and use, Ed. Houdebine LM, Harwood Academic Publishers, The Netherlands pp. 473-482.
Rudinger, 1976, Peptide Hormones, Parsons, University Park Press, Baltimore, p. 1-7.
Kaye, et al., 1990, Proc. Natl, Acad. Sci. USA, vol. 87, pp. 6922-6926.
Skolnick et al., 2000, Trends in Biotech, vol. 18, pp. 34-39.
Yanazume, Tetsuhiko et al., “Cardiac p300 Is Involved in Myocyte Growth with Decompensated Heart Failure”, Molecular and Cellular Biology, May 2003, p. 3593-3606, vol. 23, No. 10.
Gusterson, Rosalind J., et al., “The Transcriptional Co-Activators CREB-Binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That is Dependent on Their Histone Acetyltransferase Activity”, J. Biol. Chem., vol. 278, No. 9, Feb. 26, 2003, pp. 6636-6647.
Matthew, Sumy et al., “A Temary Complex of Transcription Factors, Nished and NFATc4, and Co-activator p300 bound to an Intronic Sequence, Intronic Regulatory Element, Is Pivotal for the Up-regulation of Myosin Light Chain-2v Gene in Cardiac Hypertrophy”, The Journal of Biological Chemistry, vol. 279, No. 39, Issue of Sep. 24, pp. 41018-41027, 2004.
Gen Fujii, Remi Tsuchiya, Yuzuru Itoh, Kosuke Tashiro, Setsuo Hirohashi, Molecular Cloning and expression ofXenoptisp200/CBP, Biochimica et Biophysica Acts 1443 (1998).
Tso-Pang Yao, Suk P. Oh, Miriam Fuchs, Nai-Dong Zhou, Lian-Ee ch'ng, David Newsome, Roderick T. Bronson, En Li, David M. Livingson., and Richard Eckner, Gene Dosage-Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator, Cell, vol. 93, PR, 361-372, May 1, 1998.
Hasegawa, Kouji, et al., “Kouketsuatsu-sei Shinhidai kara Shinfuzen e no Ikou ni okeru Shinkin ET-1 no Tensha Chousetsu Kikou: p300-GATA Keiro no Yakuwari” (The transcription regulation mechanism of myocardial ET-1 in the trnansition from hypertensive cardiac hypertrophy to heart failure: the role of p300-GATA pathway), Ketsuatsu, 1999, vol. 6, No. 7, pp. 665-669.
Hasegawa, Kouji, et al., “Transcriptional Coactivator p300 Stimulates Cell Type-specific Gene Expression in Cardiac Myocytes.”, J.Biol.Chem, 1997. vol. 2721, No. 32. pp. 20049-20054.
Kakita, T., et al., “A p300 Protein Is Involved in αl-Adrener-gic Agonist-stimulated Endothelin-1 Transcription in Cardiac Myocytes as a Coactivator of GATA-4/5.”, Circulation, 1999, vol. 100, No. 18, Suppl. I, pp. 213.1105.
Subramaniam, A., et al., “Tissue-specific Regulation of the α-Myosin Heavy Chain Gene Promoter in Transgenic Mice”, J.Biol.Chem., 1991, vol. 266, No. 36, pp. 24613-24620.
Kakita, T., et al., “p300 Protein as a Coactivator of GATA-5 in the Transcription of Cardiac-restricted Atrial Natriuretic Factor Gene”, J.Biol.Chem., 1999, vol. 274, No. 48, pp. 34096-34102.
Kakita, T., et al., “A nuclear Complex of PPAR/p300 Is Markedly Down-regulated in Hypertrophied Rat Left Ventricular Myocardium with Normal Systolic Function.” Circulation, 1999, vol. No. 18, Suppl. I, pp. 214, 1106.
Kakita, T., at al., “Overexpression of p300 is Sufficient to Induce Cardiac Endothelin-1 Expression and Hypertrophy in Vivo.” Circulation, 2000, vol. 102, No. 18, Suppl. II, pp. 223.
The International Search Report and International Preliminary Examination Report issued in corresponding International Application PCT/JP01/06086.
Hasegawa Koji
Kawase Yosuke
Suzuki Hiroshi
Chen Shin-Lin
Chugai Seiyaku Kabushiki Kaisha
Davidson Davidson & Kappel LLC
Hasegawa Koji
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