Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-12-25
2007-12-25
Li, Ruixiang (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C424S130100
Reexamination Certificate
active
10811198
ABSTRACT:
This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide.
REFERENCES:
patent: WO 95/10538 (1995-04-01), None
patent: WO 96/38558 (1996-12-01), None
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Boeynaems Jean-Marie
Communi Didier
Parmentier Marc
Pirotton Sabine
DeCloux Amy
Edwards Angell Palmer & Dodge
Euroscreen s.a.
Li Ruixiang
Williams Kathleen
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