Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-12-18
1998-09-15
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
536 231, 435325, 4353201, G01N 33567, C07H 2104, C12N 500, C12N 1563
Patent
active
058076921
ABSTRACT:
The striking compartmentalization of p21.sup.WAF1 expression found in normal tissues is completely abrogated in neoplastic tissues. Methods are provided for using p21.sup.WAF1 expression as a tool to assess neoplasia and to discover new drugs. A truncated p21.sup.WAF1 protein is more active than full-length p21.sup.WAF1 protein in inhibiting tumor cell growth.
REFERENCES:
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El-Deiry et al., "WAF1, a Potential Mediator of p53", Cell 75:817-825 (1993).
El-Deiry et al., "Topological Control of p21.sup.WAFI/CIP1 Expression in Normal and Neoplastic Tissues", Cancer Research 55:2910-2919 (1995).
Xiong et al., "p21 is a Universal Inhibitor of Cyclin Kinases", Nature 366:701-704 (1993).
Harper et al., "The p21 Cdk-Interacting Protein Cip 1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases", Cell 75:805-816 (1993).
Zakut et al., The Tumor Suppression Function of p21.sup.Waf is Comtained in its N-Terminal Half (`half-WAK`), Oncogene 11:393-395 (1995).
El-Deiry Wafik
Kinzler Kenneth W.
Vogelstein Bert
Campell Bruce R.
Razzaque Abour
The Johns Hopkins University
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