P2'-modified hydroxamic acid collagenase inhibitors

Details P2'-modified hydroxamic acid collagenase inhibitors P2'-modified hydroxamic acid collagenase inhibitors

1993-12-23

1995-05-02

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

560 39, 562444, C07C25550, C07C25906

Patent

active

054121450

ABSTRACT:
Compounds of general formula I: ##STR1## Wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are variables. These compounds have collagenase inhibition activity and are useful in the management of disease involving collagen degradation. Its uses include rheumatoide arthritis, corneal ulceration, osteoporosis, periodontitis, gingivitis and tumor invasion.

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Woolley et al., Arthritis and Rheumatism 29:1231-1239 (1977).
Evans, et al., J. Am. Chem. Soc. 104:1737-1739 (1982).
Cawston and Barrett, Anal. Biochem. 99:340-345 (1979).
Cawston and Murphy, Methods in Enzymology 80:711-722 (1981).

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