P2'-modified hydroxamic acid collagenase inhibitors

Details P2'-modified hydroxamic acid collagenase inhibitors P2'-modified hydroxamic acid collagenase inhibitors

1991-09-16

1994-04-05

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562451, 562623, C07C22934, C07C25906

Patent

active

053006747

ABSTRACT:
Compounds of general formula I: ##STR1## Wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are variables.
These compounds have collagenase inhibition activity and are useful in the management of disease involving collagen degradation. Its uses include rheumatoide arthritis, corneal ulceration, osteoporosis, periodontitis, gingivitis and tumour invasion.

REFERENCES:
patent: 4105789 (1978-08-01), Ondetti et al.
patent: 4496540 (1985-01-01), Kim
patent: 4599361 (1986-07-01), Dickens et al.
Woolley et al., Arthritis and Rheumatism 20 pp. 1231-1239 (1977).
Evans, et al., J. Am. Chem. Soc. 104: pp. 1737-1739 (1982).
Cawston and Barrett, Anal. Biochem. 99: pp. 340-345 (1979).
Cawston and Murphy, Methods in Enzymology 80: pp. 711-722 (1981).

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