Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
1994-04-14
2009-06-23
Ouspenski, Ilia (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S324000, C530S352000, C530S395000, C530S402000, C530S403000, C435S006120, C435S069100, C435S069700
Reexamination Certificate
active
07550561
ABSTRACT:
The present invention relates to the discovery in eukaryotic cells, particularly human cells, a novel polypeptide of 16 kDa (hereinafter “p16INK4” or “p16”) can function as an inhibitor of cell cycle progression, and therefore ultimately of cell growth, and that similar to the role of p21 and p53, the p16 protein may function coordinately with the cell cycle regulatory protein, retinoblastoma (Rb).
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Beach David H.
Demetrick Douglas J.
Hannon Gregory J.
Serrano Manuel
Cold Spring Harbor Laboratory
Ouspenski Ilia
Wilmer Cutler Pickering Hale and Dorr LLP
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