Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-07-17
1997-11-25
Ziska, Suzanne E.
Chemistry: molecular biology and microbiology
Vector, per se
4351723, 43524025, 514 44, A61K 4800, C12N 500, C12N 1500
Patent
active
056911980
ABSTRACT:
A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, expression constructs are provided that contain a p16 encoding region and other regulatory elements necessary for the expression of a p16 transcript. One version of the expression construct is a replication-deficient adenoviral vector. Also provided are methods for the transformation of cell lines and the inhibition of cancer cell proliferation.
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Jin Xiaomei
Roth Jack A.
Board of Regents , The University of Texas System
Milne Andrew
Ziska Suzanne E.
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