Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-06-23
1997-08-26
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, C12N 1563, C12P 2100
Patent
active
056609990
ABSTRACT:
There is disclosed a new calcium-regulated promoter to be used for increasing production of extracellular enzymes, or heterologous polypeptide, a recombinant vector that includes the DNA sequence of the promoter operatively linked to a DNA encoding said enzyme or polypeptide and a host organism transformed with the recombinant vector that includes the promoter operatively linked to the DNA encoding said enzyme or polypeptide. The present invention further relates to Streptomyces expression systems and methods for expressing foreign DNA sequences in Streptomyces and for secreting to the surrounding medium polypeptides and proteins coded for by those foreign DNA sequences.
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J.M. Ward et al., "Construction and charicterisation of a series of multi-copy promoter-probe plasmid vectors for Streptomyces using the aminoglyco-side phosphotransferase gene from Tn5 as indicator", Mol. Gen. Genet. (1986) 203:468-478.
M. Geistlich et al., "Localization and functional analysis of the regulated promoter from the Streptomyces glaucescens mel operon", Cell (1989) 3:1061-1069.
E. Katz et al., "Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces limidans", J. Gen. Microbiol. (1983) 129:2703:2714.
W.-M. Leu et al., "Analysis of the promoter region of the melanin locus from Streptomyces antibioticus", Gene (1989) 84:267-277.
Bernan et al. 1985 Gene 87:101-110.
Garcia Tomas Vigal
Gil Jose Antonio
Martin Juan Francisco
Ortega AntonioDaza
Guzo David
Laboratories Serono S.A.
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