P.sup.1, P.sup.4 -dithio-P.sup.2 -P.sup.3 -monochloromethylene 5

Details P.sup.1, P.sup.4 -dithio-P.sup.2 -P.sup.3 -monochloromethylene 5 P.sup.1, P.sup.4 -dithio-P.sup.2 -P.sup.3 -monochloromethylene 5

1996-05-02

1997-10-28

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514822, A61K 3170

Patent

active

056818238

ABSTRACT:
A novel composition, P.sup.1, P.sup.4 -dithio-P.sup.2, P.sup.3 -monochloromethylene 5', 5'"-diadenosine P.sup.1, P.sup.4 -tetraphosphate, is disclosed. The composition is useful as a therapeutic agent for prevention of thrombosis and for modulating a thrombolytic effect in a mammal.

REFERENCES:
patent: 5049550 (1991-09-01), Zamecnik
Zamecnik, P., et al., "Analogues of diadenosine 5',5'"-P.sup.1, P.sup.4 -tetraphosphate (Ap.sub.4 A) as potential antiplatelet-aggregation agents"; Proc. Natl., Acad. Sci. USA 89:2370-2373 (1992).
Byung, K., et al., "Antithrombotic effect of .beta.,.beta.'-monochloromethylene diadenosine 5', 5'"-P.sup.1, P.sup.4 -tetraphosphate"; Proc. Natl. Acad. Sci. USA 89:11056-11058 (1992).
Humphries, R., et al., "A novel series of P.sub.2T purinoceptor antagonists: definition of the role of ADP in arterial thrombosis"; Trends in Pharmaceutical Sci. 16:179-181 (1995).
Blackburn, G., et al., "Synthetic Structural Analogues of Dinucleoside Polyphosphates";McLennan, A. (ed.), Ap.sub.4 A and Other Dinucleoside Polyphosphates; CRC Press, Inc., Boca Raton, U.S.A.; Chapter 11 305-343 (1992).
Blackburn, G., et al., "Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate thiophosphate analogues of P.sup.1, P.sup.4 -bis (5'-adenosyl) tetraphosphate"; Nucleic Acids Research 14(17):6991-7004 (1987).
Eibl, J. et al., 124:37715s "Stable preparation for the treatment of blood coagulation disorders comprising an activated coagulation factor and lipid vesicles";CA Selects: Phospholipids (Chemical Aspects) Issue 3 (1996) Abstract.
Eibl, J. et al., 124:37716t "Stable preparation for the treatment of blood coagulation disorders comprising an activated coagulation factor and lipid vesicles";CA Selects: Phospholipids (Chemical Aspects) Issue 3 (1996) Abstract.
Byung, K. et al., "Diadenosine Tetraphosphate Analogues--Antiplatelet Effects"; SBIR I Grant Application Abstract, submitted Apr. 12, 1994.
Byung, K. et al., "Diadenosine Tetraphosphate Analogue--Antithrombotic Effect": SBIR II Grant Application Abstract, submitted Dec. 12, 1995.
Byung, K. et al., "Diadenosine Tetraphosphate Analogue--Antiplatelet Effects": SBIR Grant Abstract Project No. 1 R43 HL53864-01, submitted Apr. 12, 1994.

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