P-selectin ligand protein

Details P-selectin ligand protein P-selectin ligand protein

1995-06-07

1998-10-27

Teng, Sally P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530300, 530326, 530395, 530350, 435 691, 435 697, A61K 3817, C07K 14435, C07K 708

Patent

active

058278176

ABSTRACT:
A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

REFERENCES:
patent: 5304640 (1994-04-01), Lasky et al.
patent: 5464778 (1995-11-01), Cummings et al.
Sakao et al., Cell 75:1179-1186 (1993).
Moore et al., J. Cell Biol. 118(2):445-456 (1992).
Steininger et al., Biochem. and Biophys. Res. Comm. 188(2):760-766 (1992).
Bierhuizen and Fukuda, Proc. Nat'l. Acad. Sci USA 89:9326-9330 (1992).
Larsen et al., J. Biol. Chem. 267(16):11104-11110 (1992).
Maemura and Fukuda, J. Biol. Chem. 267(34):24379-24386 (1992).
Moore et al., J. Biol. Chem. 269(37):23318-23327 (1994).
Johnston et al., Cell 56:1033-1044 (1989).

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