P-Menthane carboxamides having a physiological cooling effect

Details P-Menthane carboxamides having a physiological cooling effect P-Menthane carboxamides having a physiological cooling effect

1974-07-08

1979-01-23

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

252110, 252522, 424 43, 424 48, 424 73, 424324, 426590, 426660, A61K 722

Patent

active

041361636

ABSTRACT:
N-substituted-p-menthane-3-carboxamides are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.

REFERENCES:
patent: 2001046 (1935-05-01), Welch
patent: 3479428 (1969-11-01), Bryce et al.
patent: 3644653 (1972-02-01), Tcheitcheff
Chemical Abstracts Subject Index, vols. 41-50, (1946-1956), pp. 3848s-3849s.
Remington's Pharmaceutical Sciences, 13th edition, (1965), p. 855.
Wilson et al., Textbook of Organic Medicinal and Pharmaceutical Chemistry, 4th edition, (1962), pp. 111-112.
Chemical Abstracts 8th Collective Index, (1967-1971), vols. 66-75, pp. 18623s-18627s.
Chemical Abstracts 7th Collective Index, (1962-1967), vols. 56-65, pp. 13780s-13782s.
Geigy et al., Chem. Abstr. 48:9610i (1954).
Kato et al., Chemical Abstr. 72:90648f.

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