Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2005-02-15
2005-02-15
Weber, Jon (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
Reexamination Certificate
active
06855812
ABSTRACT:
The invention pertains to rhesus monkey P-glycoproteins and related P-glycoproteins which include rhesus-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the rhesus monkey P-glycoprotein. The invention further relates to methods of using such rhesus monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of rhesus PGP. Also included are rhesus PGP inhibitors which inhibit rhesus PGP activity by inhibiting the expression or function of rhesus PGP.
REFERENCES:
patent: 5429921 (1995-07-01), Harpold et al.
patent: 5641508 (1997-06-01), Li et al.
patent: 5830697 (1998-11-01), Sikic et al.
patent: 6617450 (2003-09-01), Stocker et al.
patent: 6753177 (2004-06-01), Stocker et al.
patent: 20030119726 (2003-06-01), Hanscom et al.
patent: WO 8705943 (1987-10-01), None
patent: WO 9302105 (1993-02-01), None
patent: WO 9813072 (1998-04-01), None
patent: WO 199961589 (1999-12-01), None
patent: WO 0018912 (2000-04-01), None
patent: WO 0123565 (2001-04-01), None
patent: WO 200123565 (2001-04-01), None
Puel et al. Database Genbank Accession No. AAC02113. National Library of Medicine, Bethesda, MD, Jan. 28, 1998.*
Ng et al., “Identification of Members of the P-Glycoprotein Multigene Family,”Molecular and Cellular Biology, Mar. 1989, vol. 9, No. 3, pp. 1224-1232.
Gant et al., “In Vivo Induction of Liver P-Glycoprotein Expression by Xenobiotics in Monkeys,”Toxicology and Applied Pharmacology, 1995, vol. 133, pp. 269-276.
Chen et al., “Genomic Organization of the Human Multidrug Resistance (MDR1) Gene and Origin of P-glycoproteins,”The Journal of Biological Chemistry, Jan. 5, 1990, vol. 265, No. 1, pp. 506-514.
GenBank accession No. AF045016.
GenBank accession No. AF092810.
Genbank accession No. M14758.
Genbank accession No. AF016535.
Genbank accession No. NM_000927.
Sharom et al., “Interaction of the P-Glycoprotein Multidrug Transporter (MDR1) with High Affinity Peptide Chemosensitizers in Isolated Membranes, Reconstructed Systems, and Intact Cells,”Biochem. Pharmacol., 1999, vol. 58, pp. 571-586.
Sugden et al., “A Vector That Replicates as a Plasmid and can be Efficiently Selected in B-Lymphoblasts Transformed by Epstein-Barr Virus,”Mol. Cell Biol.1985, vol. 5, No. 2, pp. 410-413.
Yates et al., “Stable Replication of Plasmids Derived from Epstein-Barr Virus in Various Mammalian Cells,”Nature(Lond.) 1985, vol. 313, pp. 812-815.
Sarkadi et al., “Expression of the Human Multidrug Resistance cDNA in Insect Cells Generates a High Activity Drug-stimulated Membrane ATPase,”J. Biol. Chem.1992, vol. 267, pp. 4854-4858.
Druekes et al., “Photometric Microtiter Assay of Inorganic Phosphate in the Presence of Acid-Labile Organic Phosphates,”Anal. Biochem.1995 vol. 230, pp. 173-177.
Steingold et al., “Characterization of CanineMDR1mRNA: Its Abundance in Drug Resistant Cell Lines and in Vivo,”Anticancer Res.1998, vol. 18, pp. 393-400.
Yang et al., “Progesterone Interacts with P-Glycoprotein in Multi-resistant Cells and in the Endometrium of Gravid Uterus,”J. of Biol Chem.1989, vol. 264, No. 2, pp. 782-788.
Chen et al., Multidrug-resistant Human Sarcoma Cells with Mutant P-Glycoprotein, Altered Phenotype, and Resistance to Cyclosporins,J. of Biol. Chem.1989, vol. 272, No. 9, pp. 5974-5982.
Chen et al., “Internal Duplication and homology with Bacterial Transport Proteins in the mdr1 (P-Glycoprotein) Gene from Multidrug-Resistant Human Cells,”Cell, 1986, vol. 47, pp. 381-389.
Ambudkar et al., Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis By Human P-Glycoprotein),J. of Biolo. Chem., 1997, vol. 272, No. 34, pp: 21160-21166.
Kioka et al., “P-Glycoprotein Gene (MDR1) cDNA from Human Adrenal: Normal P-Glycoprotein Carries GLY185with an Altered Pattern of Multidrug Resistance,”Biochem. and Biophys. Res. Comm., 1989, vol. 162, No. 1, pp. 224-231.
Ma et al., Molecular Cloning, Expression and Function Characterization of the Canine Multidrug Resistance Protein (MRP1),Proc. of the Amer. Assoc. for Cancer Res. Ann., 2000, vol. 41, p. 765.
Capella et al., “Expression of Functionally P-Glycoprotein in MA104 Kidney Cells,”Zeitschrift Naturforsch.1999, vol. 54c, p. 119-127.
Schrenk et al., “Induction of Multidrug Resistance Gene Expression During Cholestasis in rats and Nonhuman Primates,”Hepatology 1993,vol. 17, pp. 854-860.
Motomura et al., “Inhibition of P-Glycoprotein and Recovery of Drug Sensitivity of Human Acute Leukemic Blast Cells by Multidrug Resistance Gene (mdr1) Antisense Oligonucleotides,”Blood, 1998, vol. 91, No. 9, pp. 3163-3171.
Romagnoli et al., “Exitope Mapping of the Monoclonal Antibody MM12.10 to External MDR1 P-Glycoprotein Domain by Synthetic Peptide Scanning and Phage Display Technologies,”Biol. Chem., 1999, vol. 380, pp. 553-559.
Fox et al., “Heterologous Expression of and the Development of Assays for Interaction of Drugs with Human P-Glycoprotein,”Drug Metab. Revs., 2000, vol. 32(Supp 1), p. 41 (ABSTRACT).
International Search Report in PCT Application No. PCT/US02/08325, mailed Aug. 13, 2003.
International Preliminary Examination Report in PCT Application No. PCT/US02/08325, mailed Jun. 25, 2004.
Crespi Charles
Hanscom Sara
Becton Dickinson and Company
Snedden Sheridan
Weber Jon
Wolf Greenfield & Sacks P.C.
LandOfFree
P-glycoproteins and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with P-glycoproteins and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and P-glycoproteins and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3472222