P-glycoprotein inhibitor, method for preparing the same and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S381000, C546S148000, C548S253000

Reexamination Certificate

active

07625926

ABSTRACT:
The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

REFERENCES:
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patent: 10-580743 (2006-05-01), None
patent: WO 92/7844 (1992-05-01), None
patent: WO 94/01408 (1994-01-01), None
patent: WO 98/17648 (1998-04-01), None
patent: WO 03/095447 (2003-11-01), None
M. Roe et al., “Reversal of P-Glycoprotein Media Multidrug Resistance by Novel Anthranilamide Derivatives”, Bioorganic & Medicinal Chemistry Letters 9, (4), 1999, pp. 595-600.
P. Mistry et al., “In Vitroandin Vivo Reversal of P-Glycoprotein-mediated Multidrug Resistance by a Novel Potent Modulator, XR9576”, Cancer Research, 61 (2), Jan. 15, 2001.
A. Stewart et al., “Phase I Trial of XR9576 in Healthy Volunteers Demonstrates Modulation of P-Glycoprotein in CD56+Lymphocytes after Oral and Intravenous Administration”, Clinical Cancer Research, vol. 6, Nov. 2000, pp. 4186-4191.
W. Shouming et al., “Studies on Quinazolinones as Dual Inhibitors of Pgp and MRP1 in Multidrug Resistance”, Bioorganic & Medicinal Chemistry Letters, 2002, vol. 12, No. 4, pp. 571-574.
M.N. Borrel et al., “Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4′-O-tetrahydropyranyladriamycin incorporation in K562 drug-resistant cells”, European Journal of Biochemistry, 1994, vol. 233, No. 1, pp. 125-133.
W.N. Hait et al., “Rational design and preclinical pharmacology of drugs for reversing multidrug resistance”, Biochemical Pharmacology, 1992, vol. 43, No. 1, pp. 103-107.

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