Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1989-05-18
1992-05-19
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Lymphokine
530324, 530326, 530350, A61K 3900, A61K 3702
Patent
active
051147130
ABSTRACT:
The present invention relates to the use of a peptide from the circumsporozoite (CS) protein of Plasmodium falciparum (P. falciparum) and the derivatives thereof as a universally recognized T-cell epitope i.e. an epitope which is recognized in association with many different human and mouse major histocompatibility complex (MHC) haplotypes e.g. in the context of the human MHC class II molecules such as DR1, DR2, DR4, DR5, DRw6, DR7 or DR9. Furthermore the present invention relates to the above-mentioned peptide per se and to immunogenic compositions comprising such a peptide or a derivative thereof. These immunogenic compositions can be used as vaccines to elicit a durable immune response against a pathogenic agent in humans and animals irrespective of the MHC haplotype of the host.
REFERENCES:
patent: 4826957 (1989-05-01), Nussenzweig et al.
patent: 4886782 (1989-12-01), Good et al.
patent: 4915942 (1990-04-01), Vergara et al.
Modern Approaches to New Vaccines Including Prevention of AIDS, Abstracts, Sep. 9-13, 1987, p. 114.
Sinigaglia, et al., European Journal of Immunology, 18:633 (1988).
Chemical Abstracts (106:16623y) 1987.
Chemical Abstracts (107:161463w) 1987.
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Roseman Catherine R.
Waddell Frederick E.
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