P. exotoxin fusio proteins have COOHG220101al alterations which

Details P. exotoxin fusio proteins have COOHG220101al alterations which P. exotoxin fusio proteins have COOHG220101al alterations which

1990-05-14

1995-10-17

Lacey, David L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242791, 435 697, 5303873, 5303917, A61K 39104, C07K 300, C07K 1528, C12P 2108

Patent

active

054588782

ABSTRACT:
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional, recombinant, cytotoxic fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.

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