Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Stabilized enzymes or enzymes complexed with nonenzyme
Patent
1986-08-29
1989-02-28
Naff, David M.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Stabilized enzymes or enzymes complexed with nonenzyme
424 9464, 435174, 435188, 435216, 514802, A61K 3747, A61K 37547, C12N 1100, C12N 970
Patent
active
048084050
ABSTRACT:
A binary complex between streptokinase and plasminogen is prepared in which the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis such that the pseudo-first order rate constant for hydrolysis of the complex is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C. The complex is preferably a p-anisoyl streptokinase/plasminogen complex without internal peptide bond cleavage. The complex is useful in the treatment of venous thrombosis.
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patent: 4285932 (1981-08-01), Smith
McClintock et al., Biochemical and Biophysical Research Communications, vol. 43, No. 3, 1971, pp. 694-702.
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Brockaway et al., Biochem., 13, 2063-2069 (1974).
Abstract P5-076 0929, Thrombosis & Haemostasis, (Stuttgart), 42, 390 (1979).
Smith Richard A. G.
Winchester John G.
Beecham Group p.l.c.
Naff David M.
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