Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-07-30
1992-04-28
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514356, 514399, 514486, 514490, 546326, 548341, 562555, A61K 3144, A61K 31415, C07D21178, C07D23354
Patent
active
051090112
ABSTRACT:
This invention relates to p-acylaminophenoxycarbamates having the formula ##STR1## where R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, aryl and arylloweralkyl; R.sub.3 is hydrogen, loweralkyl, aryllowerallkyl; R.sub.4 is hydrogen, loweralkyl, formyl, alkylcarbonyl, arylloweralkyl, phenylcarbonyl, arylloweralkylcarbonyl, substituted phenylcarbonyl, pyridylcarbonyl, and substituted pyridylcarbonyl with the proviso that if R.sub.4 contains a carbonyl group directly attached to the oxygen of the N-O moiety, R.sub.3 cannot by hydrogen; or R.sub.3 and R.sub.4 taken together form a heterocyclic ring selected from the group consisting of imidazole or loweralkylimidazole; X is hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; and p is an integer selected from 0 and 1; the pharmaceutically acceptable acid addition salts thereof, and where applicable, the geometric and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics.
REFERENCES:
Nippon Oyo Dobutsu Konchu Gakkai-Shi, vol. 12, No. 4, 1968, 202-210.
A. L. Black et al., An Evaluation of Aminozectran and Carbofuran Derivatives as Mothproofers, J. Text. Int. 1976, No. 2, pp. 68-70.
CA 73 (11):54978a (1968).
CA 84 (20):137085k (1976).
CA 96 (25):217485d (1982).
CA 96:217485d, Jun. 1982 Analgesic Phenyl Carbamates JP 82 07,459, p. 705.
Allen Richard C.
Kosley, Jr. Raymond W.
Spahl Bettina
Hoechst-Roussel Pharmaceuticals Incorporated
Korsen Elliott
Lee Mary C.
McKane Joseph K.
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