P-Acetaminophenyl phosphate salts as analgesics and antipyretics

Details P-Acetaminophenyl phosphate salts as analgesics and antipyretics P-Acetaminophenyl phosphate salts as analgesics and antipyretics

1979-12-04

1982-03-30

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

260924, 260944, 424211, 536 27, A61K 3171, C07F 909

Patent

active

043224105

ABSTRACT:
The invention relates, as an analgesic and antipyretic medicine, to a paracetamol derivative highly soluble in water, namely the p-acetaminophenyl phosphate in the form of its salts, with pharmaceutically suitable mineral and organic bases, and in particular sodium, glycine, lysine and adenosine salts.
The invention further relates to a process for the preparation of p-acetaminophenyl phosphate from the p-nitrophenol phosphoric ester.

REFERENCES:
patent: 2023551 (1935-12-01), Rosenzweig
patent: 3032555 (1962-05-01), Oxley et al.
patent: 3107262 (1963-10-01), Rochen
Buehler, et al., "Survey of Organe Syntheses", Wiley-Interscience, New York, (1974), pp. 413-414.
Bollinger, "Chem. Abs.", vol. 43 (1949), p. 173 g & h.
Houben-Weyl, vol. 12, No. 7, p. 161.
Galstakhoua, et al., "Chem. Abstracts", vol. 81 (1979). 25304n.
Bellstein, (1951), p. 494.

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