Oxytocin and vasopressin antagonists

Details Oxytocin and vasopressin antagonists Oxytocin and vasopressin antagonists

1990-10-23

1992-03-10

Doll, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530315, 530317, 530333, 514807, 435 78, 435 71, 435 711, 435 74, 435 76, 436501, A61K 3734, C07K 716

Patent

active

050950037

ABSTRACT:
Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

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J. C. S. Chem. Comm. p. 635 (1977), Hassall et al.
Tetrahedron Letters, 49, pp. 4255-4258 (1969), Hammill et al.

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