Oxysulfonyl urea ACAT inhibitors

Details Oxysulfonyl urea ACAT inhibitors Oxysulfonyl urea ACAT inhibitors

1991-07-26

1993-03-30

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558 50, A61K 31255, C07C30963

Patent

active

051984660

ABSTRACT:
Novel compounds of the formula ##STR1## wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R.sub.1 and R.sub.2 is hydrogen, an aralkyl group, a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and may be saturated or unsaturated, an alkyl group of from 1 to 6 carbon atoms wherein the terminal carbon is substituted, the group --(CH.sub.2).sub.p)--Q wherein p is zero to three and Q is a 5- or 6-membered monocyclic or fused bicyclic heterocycle, phenyl or NR.sub.1 R.sub.2 taken together form a monocyclic heterocyclic ring, and R.sub.3 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, --(CH.sub.2).sub.p --Q wherein p and Q are as defined above, an aralkyl group or a straight or branched hydrocarbon group having from 1 to 20 carbon atoms and being straight or branched.

REFERENCES:
Chem.Ber. 100, 2938-2945 (1967), W. Bartmann, "Reaktionen von Sulfonylisocyanaten mit CN-Doppelbindungen", being translated.
Chem.Ber. 105, 2800-2804 (1972), R. Lattrell et al., "Alkoxysulfonylisocyanate", being translated.
Tetrahedron Letters, 24, (30), 3091-3094, (1983), J. Montero, et al., "Selective Synthesis of Sulfonylureas and Carboxysulfamides, A Novel Route to Oxazolidinones".

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