Oxygenated-heterocycle containing sulfonamide inhibitors of aspa

Details Oxygenated-heterocycle containing sulfonamide inhibitors of aspa Oxygenated-heterocycle containing sulfonamide inhibitors of aspa

1997-11-24

1999-11-23

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549396, A61K 3135, C07D31100

Patent

active

059901551

ABSTRACT:
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.

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