Oxygen-transferable emulsion

Details Oxygen-transferable emulsion Oxygen-transferable emulsion

1974-02-04

1976-06-08

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424267, 424278, 424283, 424285, 424325, 424342, 424352, A61K 31535, A61K 31445, A61K 31335, A61K 3135

Patent

active

039624390

ABSTRACT:
Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.

REFERENCES:
malchesky et al. - Chem. Abst., vol. 74 (1971), p. 51336z.
Watanabe et al. - Chem. Abst., vol. 76 (1972), p. 131465x.
Samejima et al. - Chem. Abst., vol. 78 (1973), p. 71384z.
Samejima et al. - Chem. Abst., vol. 79 (1973), p. 70220b.
Clark et al. - Fed. Proc. vol. 29 (1970), pp. 1764-1766.

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