Oxygen delivery agents and uses for the same

Details Oxygen delivery agents and uses for the same Oxygen delivery agents and uses for the same

1997-06-18

2003-03-25

Bockelman, Mark (Department: 3762)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C222S145500, C222S145600, C222S146200, C424S450000

Reexamination Certificate

active

06537246

ABSTRACT:

FIELD OF THE INVENTION
The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, methods of using the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery agents or blood substitutes.
BACKGROUND OF THE INVENTION
A theoretical assessment of oxygen delivery agents and the efficacy of loading and unloading oxygen is described from the standpoint of the partial pressures of oxygen in the lungs, blood, and tissues by Van Liew, et al.,
J. Appl. Physiol.,
81(1):500-508 (1996), and Burkard et al,
J. Appl. Physiol.,
77(6):2874-2878 (1994). Liquid perfluorocarbons, such as perfluorooctylbromide, perfluorodecalin, perfluorotripropylamine and perfluorotributylamine, have been investigated as oxygen-transporting blood substitutes by, for example, Lowe,
Comp. Biochem. Physiol.,
87A:825-838 (1987). However, these liquid perfluorocarbons boil at temperatures far above physiological conditions, and thus have a limited ability to thermally expand. This limitation imposes a practical constraint on the amount of infused liquid perfluorocarbon that may be administered to a patient in need of an oxygen-carrying blood substitute. Toxicity problems associated with liquid perfluorocarbon emulsions have also imposed significant limitations on their use, as described, for example, by Jing and Cooper,
Biomat. Art. Cells Art. Org.,
18:107-117 (1990).
There is a need for oxygen delivery agents or blood substitutes that overcome the problems associated with the prior art. The present invention is directed to these, as well as other, important ends.
SUMMARY OF THE INVENTION
The present invention describes a method for oxygen delivery comprising administering to a patient a composition, in an aqueous carrier, comprising a fluorinated gas and a stabilizing material. The composition may further comprise oxygen before it is administered to the patient, or it may be administered without oxygen, whereby oxygen is added to the composition by the patient's own respiratory processes upon circulation through the patient's lungs. The method may also comprise imaging the patient with diagnostic ultrasound to monitor the location of the composition and applying therapeutic ultrasound to the patient to facilitate delivery of the oxygen in a desired region of the patient. The stabilizing material may be in a vesicular or non-vesicular form, as desired.
In another embodiment, the present invention describes an oxygen delivery vehicle or blood substitute comprising a composition which comprises a fluorinated gas and a stabilizing material. The composition further comprises oxygen. Preferably, the composition further comprises an aqueous carrier. The stabilizing material may be in a vesicular or non-vesicular form, as desired.
In another embodiment, the present invention describes an apparatus for making an oxygen delivery agent. The apparatus comprises (i) a first vessel containing a stabilizing material, (ii) a second vessel containing a fluorinated compound, (iii) means for mixing the stabilizing material and the fluorinated compound so as to form an oxygen delivery agent. In a preferred embodiment, the apparatus also includes a supply of oxygen and means for introducing oxygen from the supply into the mixture so as to form an oxygen carrying oxygen delivery agent. Preferably, at least one of the vessels is formed by the barrel of a syringe. In one embodiment, the mixing means comprises (i) a device for inducing turbulence into the mixture of stabilizing material and fluorinated compound and (ii) a device for agitating the mixture. The apparatus may further comprise a device for evacuating the contents of the vessels. In one embodiment, the evacuation device comprises a programmable mechanical injector. In another embodiment, the evacuation device comprises a disposable pressurized gas cylinder.
These and other aspects of the invention will become more apparent from the following detailed description.


REFERENCES:
patent: 3015128 (1962-01-01), Sommerville et al.
patent: 3291843 (1966-12-01), Fritz et al.
patent: 3293114 (1966-12-01), Kenaga et al.
patent: 3401475 (1968-09-01), Morehouse et al.
patent: 3479811 (1969-11-01), Walters
patent: 3488714 (1970-01-01), Walters et al.
patent: 3532500 (1970-10-01), Priest et al.
patent: 3557294 (1971-01-01), Dear et al.
patent: 3594326 (1971-07-01), Himmel et al.
patent: 3615972 (1971-10-01), Morehouse et al.
patent: 3650831 (1972-03-01), Jungermann et al.
patent: 3732172 (1973-05-01), Herbig et al.
patent: 3873564 (1975-03-01), Schneider et al.
patent: 3945956 (1976-03-01), Garner
patent: 3960583 (1976-06-01), Netting et al.
patent: 3968203 (1976-07-01), Spitzer et al.
patent: 4027007 (1977-05-01), Messina
patent: 4044757 (1977-08-01), McWhorter et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4108806 (1978-08-01), Cohrs et al.
patent: 4138383 (1979-02-01), Rembaum et al.
patent: 4162282 (1979-07-01), Fulwyler et al.
patent: 4179546 (1979-12-01), Garner et al.
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4303736 (1981-12-01), Torobin
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4315514 (1982-02-01), Drewes et al.
patent: 4331654 (1982-05-01), Morris
patent: 4344929 (1982-08-01), Bonsen et al.
patent: 4420442 (1983-12-01), Sands
patent: 4421562 (1983-12-01), Sands
patent: 4426330 (1984-01-01), Sears
patent: 4427649 (1984-01-01), Dingle et al.
patent: 4428924 (1984-01-01), Millington
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4512764 (1985-04-01), Wensh
patent: 4530360 (1985-07-01), Duarte
patent: 4533254 (1985-08-01), Cooks et al.
patent: 4534899 (1985-08-01), Sears
patent: 4540629 (1985-09-01), Sands et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4549892 (1985-10-01), Baker et al.
patent: 4569836 (1986-02-01), Gordon
patent: 4572203 (1986-02-01), Feinstein
patent: 4582756 (1986-04-01), Niinuma
patent: 4586512 (1986-05-01), Do-huu et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4615879 (1986-10-01), Runge et al.
patent: 4620546 (1986-11-01), Aida et al.
patent: 4625494 (1986-12-01), Iwatschenko et al.
patent: 4646756 (1987-03-01), Watmough et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4658828 (1987-04-01), Dory
patent: 4663161 (1987-05-01), Mannino et al.
patent: 4675310 (1987-06-01), Chapman et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4689986 (1987-09-01), Carson et al.
patent: 4693999 (1987-09-01), Axelsson et al.
patent: 4718433 (1988-01-01), Feinstein
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4728578 (1988-03-01), Higgins et al.
patent: 4731239 (1988-03-01), Gordon
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774958 (1988-10-01), Feinstein
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4781871 (1988-11-01), West, III et al.
patent: 4789501 (1988-12-01), Day et al.
patent: 4790891 (1988-12-01), Halliday et al.
patent: 4822534 (1989-04-01), Lencki et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 4834964 (1989-05-01), Rosen
patent: 4844882 (1989-07-01), Widder et al.
patent: 4863717 (1989-09-01), Keana
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4893624 (1990-01-01), Lele
patent: 4895719 (1990-01-01), Radhakrishnan
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4918065 (1990-04-01), Stindl et al.
patent: 4919895 (1990-04-01), Heldebrant et al.
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4933121 (1990-06-01), Law et al.
patent: 4938947 (1990-07-01), Nicolau et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4972002 (19

Affiliated with

Also associated with

Rating

Oxygen delivery agents and uses for the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxygen delivery agents and uses for the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxygen delivery agents and uses for the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3081973