Oxygen-18 labeled organic acids and use in diagnosing...

Chemistry: analytical and immunological testing – Oxygen containing – Carbonyl – ether – aldehyde or ketone containing

Reexamination Certificate

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C436S127000, C436S173000

Reexamination Certificate

active

07993931

ABSTRACT:
Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic acid through processing required for its detection, such as by mass spectrometry. The methods of the invention are useful for diagnosing inborn errors of metabolism in an individual by quantitating signature organic acids in body fluids such as urine or plasma.

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